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Targeted Allele Detail
Symbol: Isl1tm1Gan
Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Lin Gan
MGI ID: MGI:3790243
Synonyms: Isl1lacZ, IsllacZ
Gene: Isl1  Location: Chr13:116298281-116309689 bp, - strand  Genetic Position: Chr13, 64.87 cM, cytoband D2.3
Germline Transmission:  Earliest citation of germline transmission: J:134563
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe region between the initiation methionine condon in exon 1 through all of exon 2 was replaced with a lacZ cassette. Expression of LacZ was detected in amacrine cells of the retina. (J:134563)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Isl1 Mutation:  19 strains or lines available
Original:  J:134563 Elshatory Y, et al., Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. J Comp Neurol. 2007 Jul 1;503(1):182-97
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory