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Itgavtm1Blb
Targeted Allele Detail
Nomenclature
Symbol: Itgavtm1Blb
Name: integrin alpha V; targeted mutation 1, Bernhard L Bader
MGI ID: MGI:3790236
Synonyms: alphavflox
Gene: Itgav  Location: Chr2:83724397-83806916 bp, + strand  Genetic Position: Chr2, 49.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134784
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient flp expression in ES cells was used to remove the neo cassette leaving exon 1 floxed. (J:134784)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgav Mutation:  6 strains or lines available
References
Original:  J:134784 Lammermann T, et al., Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature. 2008 May 1;453(7191):51-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory