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Upf2tm1Btp
Targeted Allele Detail
Nomenclature
Symbol: Upf2tm1Btp
Name: UPF2 regulator of nonsense transcripts homolog (yeast); targeted mutation 1, Bo Torben Porse
MGI ID: MGI:3790198
Synonyms: Upf2fl
Gene: Upf2  Location: Chr2:5951469-6056703 bp, + strand  Genetic Position: Chr2, 3.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:134765
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt-flanked neo/STOP cassette with a 5' loxP site was inserted downstream of exon 3 and an additional loxP site was inserted upstream of exon 2. Germ line, flp mediated deletion was used to remove the neo/STOP cassette leaving exons 2 and 3 floxed. (J:134765)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 164986 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Upf2 Mutation:  40 strains or lines available
References
Original:  J:134765 Weischenfeldt J, et al., NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev. 2008 May 15;22(10):1381-96
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory