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Tg(Camk2a-ESR1/Disc1*)2698.1Sva
Transgene Detail
Nomenclature
Symbol: Tg(Camk2a-ESR1/Disc1*)2698.1Sva
Name: transgene insertion 2698.1, Alcino J Silva
MGI ID: MGI:3785794
Synonyms: DISC-cc, LBDG521R-DISC1-cc
Transgene: Tg(Camk2a-ESR1/Disc1*)2698.1Sva  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Camk2a-ESR1/Disc1*)2698.1Sva expresses 1 gene
 
Mutation detailsThe transgene construct is composed of a mouse a-calmodulin kinase II promoter, a hybrid intron in the 5' untranslated leader, a HA virus-tag sequence, and a mutant form of the estrogen ligand biding domain (LBDG521R) cDNA fused 5' to a truncated mouse DISC1 cDNA (DISC1-cc; encoding the C-terminal protein residues 671-852), and a polyA sequence. Upon tamoxifen induction of fusion gene expression, the LBDG521R-DISC1-cc fusion protein is directed to the cortex, hippocampus, striatum, and cerebellum by the CaMKIIa promoter. Immunohistochemical expression of mutant protein is observed in the forebrain in the branches and cytoplasm of neurons. (J:127235)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:127235 Li W, et al., Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18280-5
All:  2 reference(s)

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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory