Ltb4r2^tm1Tksh
Targeted Allele Detail

Summary

• Symbol: Ltb4r2^tm1Tksh
• Name: leukotriene B4 receptor 2; targeted mutation 1, Takao Schimizu
• MGI ID: MGI:3785609
• Synonyms: BLT2-KO
• Gene: Ltb4r2 Location: Chr14:55998885-56002595 bp, + strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ltb4r2^tm1Tksh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133998
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ and neomycin resistance cassette inserted into the open reading frame. QRT-PCR confirmed the absence of transcript expression in the skin, colon and small intestine. Expression of Cideb (an overlapping gene on the opposite strand) is normal. (J:202094)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ltb4r2 Mutation: 16 strains or lines available

References

• Original: J:133998 Okuno T, et al., 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J Exp Med. 2008 Apr 14;205(4):759-66
• All: 9 reference(s)