Gpx4^tm1Ssd
Targeted Allele Detail

Summary

• Symbol: Gpx4^tm1Ssd
• Name: glutathione peroxidase 4; targeted mutation 1, Samir S Deeb
• MGI ID: MGI:3785543
• Gene: Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gpx4^tm1Ssd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134214
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 through part of exon 2 was replaced with a lacZ reporter gene and a neo cassette. Mice heterozygous for the allele exhibit a 37% drop in protein product activity in testies and 22% in the liver. (J:134214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx4 Mutation: 80 strains or lines available

References

• Original: J:134214 Garry MR, et al., Sensitivity of mouse lung fibroblasts heterozygous for GPx4 to oxidative stress. Free Radic Biol Med. 2008 Mar 15;44(6):1075-87
• All: 1 reference(s)