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Mus81tm1Esse
Targeted Allele Detail
Nomenclature
Symbol: Mus81tm1Esse
Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Jeroen Essers
MGI ID: MGI:3785405
Synonyms: Efemp2/Mus81tm1Esse, Fibulin-4R
Gene: Mus81  Location: Chr19:5482345-5488402 bp, - strand  Genetic Position: Chr19, 4.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133703
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 10 of Mus81 were replaced with a neo cassette. Reduction in expression of transcripts for both Mus81 and the neighboring gene Efemp2 was confirmed by quantitative RT-PCR on embryonic fibroblasts extracts. (J:133703)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 18 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mus81 Mutation:  7 strains or lines available
References
Original:  J:133703 Hanada K, et al., Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res. 2007 Mar 16;100(5):738-46
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory