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Tom1l2Gt(XG909)Byg
Gene trapped Allele Detail
Summary
Symbol: Tom1l2Gt(XG909)Byg
Name: target of myb1-like 2 (chicken); gene trap XG909, BayGenomics
MGI ID: MGI:3784979
Gene: Tom1l2  Location: Chr11:60117540-60243731 bp, - strand  Genetic Position: Chr11, 37.81 cM
Alliance: Tom1l2Gt(XG909)Byg page
Splenomegaly in Tom1l2Gt(XG909)Byg/Tom1l2Gt(XG909)Byg mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  XG909
Germline Transmission:  Earliest citation of germline transmission: J:133892
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT1Lxf     Vector Type: gene trap
 
Mutation detailsThe gene trap vector pGT1lxf that contains the beta-geo cassette was inserted between exon 10 and 11. This allele is a reporter allele and a hypomorphic allele with reduced expression in the brain (80% reduction), liver (70% reduction) and spleen (50% reduction) of homozygotes as detected by semi-quantitative RT-PCR. (J:133892)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 19 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tom1l2Gt(XG909)Byg
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tom1l2 Mutation:  48 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
References
Original:  J:133892 Girirajan S, et al., Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response. Mamm Genome. 2008 Apr;19(4):246-62
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory