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Nupr1tm1Jlio
Targeted Allele Detail
Nomenclature
Symbol: Nupr1tm1Jlio
Name: nuclear protein transcription regulator 1; targeted mutation 1, Juan Lucio Iovanna
MGI ID: MGI:3784016
Synonyms: p8-
Gene: Nupr1  Location: Chr7:126623249-126630861 bp, - strand  Genetic Position: Chr7, 69.21 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133728
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 is replaced by a neomycin cassette in reverse orientation. Loss of protein product in the pancreas was confirmed by Western blot analysis. (J:133728)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nupr1 Mutation:  3 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Sertoli cell only syndrome in in homozygous mice (J:140899)
References
Original:  J:133728 Vasseur S, et al., p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis. Oncogene. 2002 Mar 7;21(11):1685-94
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory