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Tpsb2tm1.1Mfg
Targeted Allele Detail
Nomenclature
Symbol: Tpsb2tm1.1Mfg
Name: tryptase beta 2; targeted mutation 1.1, Michael F Gurish
MGI ID: MGI:3783331
Synonyms: Mcpt6-, mMCP-6-, Tpsb2tm1Dle
Gene: Tpsb2  Location: Chr17:25366550-25368094 bp, + strand  Genetic Position: Chr17, 12.53 cM, cytoband A3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133373
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsParts of exon 2 and 3 were replaced with an EGFP expression cassette followed by two polyA stop sequences and a loxP-flanked neomycin resistance cassette. Founder mice were mated with cre transgenic mice to remove the neomycin selection cassette. Gene inactivation was confirmed by immunoblot analysis on bone marrow derived mast cells. Immunoblot analysis also confirmed that the adjacent Tpsab1 gene locus contained the intact 129 allele and not the null C57BL/6 allele. (J:133373)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tpsb2 Mutation:  4 strains or lines available
References
Original:  J:133373 Shin K, et al., Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection. J Immunol. 2008 Apr 1;180(7):4885-4891
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory