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Mfn2tm3Dcc
Targeted Allele Detail
Nomenclature
Symbol: Mfn2tm3Dcc
Name: mitofusin 2; targeted mutation 3, David C Chan
MGI ID: MGI:3779081
Synonyms: Mfn2loxP
Gene: Mfn2  Location: Chr4:147958056-147989161 bp, - strand  Genetic Position: Chr4, 78.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132329
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsFRT-flanked neo cassette followed by two loxP sites flanking the exon 6 encoding the canonical G-1 GTPase motif replaced the endogenous locus. The neo cassette was removed by crossing with FLP recombinase expressing mice. (J:132329)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mfn2 Mutation:  22 strains or lines available
References
Original:  J:132329 Chen H, et al., Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell. 2007 Aug 10;130(3):548-62
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory