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Mfn1tm2Dcc
Targeted Allele Detail
Nomenclature
Symbol: Mfn1tm2Dcc
Name: mitofusin 1; targeted mutation 2, David C Chan
MGI ID: MGI:3779080
Synonyms: Mfn1loxP
Gene: Mfn1  Location: Chr3:32529465-32579239 bp, + strand  Genetic Position: Chr3, 15.75 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132329
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsFRT-flanked neo cassette followed by two loxP sites flanking the exon 4 encoding the canonical G-1 GTPase motif replaced the endogenous locus. The neo cassette was removed by crossing with FLP recombinase expressing mice. (J:132329)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mfn1 Mutation:  10 strains or lines available
References
Original:  J:132329 Chen H, et al., Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell. 2007 Aug 10;130(3):548-62
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory