Bwiq4^SM/J
QTL Variant Detail

Summary

• QTL variant: Bwiq4^SM/J
• Name: body weight and composition imprinted QTL 4; SM/J
• MGI ID: MGI:3778999
• QTL: Bwiq4 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:133354

Whole genome scan was performed on 1632 animals from a (LG/J x SM/J)F3 cross to identify imprinted genetic loci associated with body composition traits. Parental strain LG/J is heavier than SM/J animals by 16 to 20 grams. A panel of 353 SNP markers at a resolution of 4 cM - 5 cM was used for linkage analysis. All genotypes and parent-of-origin information were used in the analysis.

Significant linkage to imprinting effects on kidney weight and heart weight mapped to 29.5 cM (57.6 Mb) on mouse Chromosome 3 near rs6363066 (LPR=6.1). This locus is named Bwiq1 (body weight and composition imprinted QTL 1). Bipolar and polar under-dominance imprinting patterns were observed for kidney weight and heart weight at Bwiq1, respectively. A second locus named Bwiq2 mapped to 51 cM (107.3 Mb) near rs3684333 (LPR=13.1). Maternal imprinting effects on spleen weight and tail length are observed at Bwiq2. In addition, bipolar imprinting effects for liver and heart weight, polar under-dominance imprinting for body weight, and paternal imprinting for kidney weight were also observed at Bwiq2.

On mouse Chromosome 4, bipolar imprinting effects on kidney weight mapped to 1.3 cM (6.3 Mb) near rs13477541 (LPR=5.24). This locus is named Bwiq3 (body weight and composition imprinted QTL 3).

Suggestive linkage to imprinting effects on liver, spleen, and body weight mapped to 86 cM (151.1 Mb) mouse Chromosome 5 near rs13478595 (LPR=3). Polar over-dominance imprinting was observed for liver and spleen weight while body weight displayed a maternal parent-of-origin effect.

On mouse Chromosome 6, linkage to fat pad weight mapped to 37 cM (89.6 Mb) near rs13478882 (LPR=23.3). Upon further investigation it was determined this locus has a maternal parent-of-origin effect andis not imprinted. This QTL is designated Bwmq1 (body weight and composition maternal effect QTL 1).

Bwiq4 (body weight and composition imprinted QTL 4) mapped to 60 cM (123 Mb) on mouse Chromosome 7 near rs3656074 (LPR=15.9). This locus is linked to paternal imprinting effects on liver weight, fat pad weight, and body weight. Bwiq4 is also linked to bipolar imprinting effects on heart and kidney weight. Potential candidates in this region include the paternally expressed gene Inpp5f at 128.4 Mband Igf2 at 142.5 Mb.

On mouse Chromosome 12, significant linkage to imprinting effects on liver, fat pad, kidney, and body weight mapped to 22 cM (54 Mb) near rs3670749 (LPR=9.6). This locus is named Bwiq5 (body weight and composition imprinted QTL 5).Polar over-dominanceimprinting patterns are observed for liver and kidney weight while paternal imprinting effects are observed for fat pad and body weight.

Significant linkage to liver weight, tail length, and body weight mapped to 41 cM (66 Mb) on mouse Chromosome 18 near rs13483409 (LPR=6.8). This locus is named Bwiq6 (body weight and composition imprinted QTL 6). Liver weight and tail length display bipolar imprinting patterns at Bwiq6 while body weight displays paternal imprinting. Suggestive linkage to imprinting effects on liver, fat pad, kidney, spleen, and body weight mapped near UT1833.980716 (LPR=4.4). Bipolar imprinting was observed for liver, kidney, and spleen weight while paternal imprinting was observed for fat pad and spleen weight. Apotential candidate gene for this suggestive locus is the Impact gene (imprinted and ancient) at 131.15 Mb. Impact displays a paternal allele expression in brain tissue.

References

• Original: J:133354 Cheverud JM, et al., Genomic imprinting effects on adult body composition in mice. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4253-8
• All: 1 reference(s)