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Targeted Allele Detail
Symbol: Grhl1tm1Jane
Name: grainyhead like transcription factor 1; targeted mutation 1, Stephen M Jane
MGI ID: MGI:3778923
Gene: Grhl1  Location: Chr12:24572283-24617391 bp, + strand  Genetic Position: Chr12, 8.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:133318
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a lacZ and floxed neo cassette. The neo cassette was subsequently removed by germ-line, cre-mediated recombination. The absence of transcript was confirmed by RT-PCR on brain, kidney, testis, lung, stomach, liver, spleen, thymus, heart, and skin extracts. This is a null allele. (J:133318)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grhl1 Mutation:  23 strains or lines available
Original:  J:133318 Wilanowski T, et al., Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J. 2008 Mar 19;27(6):886-97
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory