Gt(ROSA)26Sor^{tm3(CAG-MIR17-92,-EGFP)Rsky}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(CAG-MIR17-92,-EGFP)Rsky}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Klaus Rajewsky
• MGI ID: MGI:3778920
• Synonyms: Gt(ROSA)26Sor^{tm3(CAG-MIRN17-92,-EGFP)Rsky}, Gt(ROSA)26Sor^tm3Rsky, miR-17-92^TG, miRNA-17-92^OE
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(CAG-MIR17-92,-EGFP)Rsky} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133215
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing the chicken beta actin promoter CAG driving the expression of a floxed neo-STOP cassette followed by cDNA encoding human MIRN 17, 18a, 19a, 20a, 19b and 92 plus an frt-flanked IRES-EGFP cassette and a poly-adenylation site were inserted into the ROSA locus. This allele is also a knockin allele that allows for expression of the human MIRNs contained within it following the cre-mediated removal of the neo-STOP cassette. (J:133215)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^{tm3(CAG-MIR17-92,-EGFP)Rsky}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:133215 Xiao C, et al., Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol. 2008 Apr;9(4):405-14
• All: 31 reference(s)