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Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm3(CAG-MIR17-92,-EGFP)Rsky
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Klaus Rajewsky
MGI ID: MGI:3778920
Synonyms: Gt(ROSA)26Sortm3(CAG-MIRN17-92,-EGFP)Rsky, Gt(ROSA)26Sortm3Rsky, miR-17-92TG, miRNA-17-92OE
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:133215
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, No functional change, Reporter)
Mutation:    Insertion
 
Mutation detailsA cassette containing the chicken beta actin promoter CAG driving the expression of a floxed neo-STOP cassette followed by cDNA encoding human MIRN 17, 18a, 19a, 20a, 19b and 92 plus an frt-flanked IRES-EGFP cassette and a poly-adenylation site were inserted into the ROSA locus. This allele is also a knockin allele that allows for expression of the human MIRNs contained within it following the cre-mediated removal of the neo-STOP cassette. (J:133215)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
References
Original:  J:133215 Xiao C, et al., Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat Immunol. 2008 Apr;9(4):405-14
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory