Socs1^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Socs1^tm1Ayos
• Name: suppressor of cytokine signaling 1; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:3778686
• Synonyms: SOCS1^fl
• Gene: Socs1 Location: Chr16:10601672-10603400 bp, - strand Genetic Position: Chr16, 5.81 cM
• Alliance: Socs1^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132905
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in exon 2 downstream of the coding region and an additional loxP site was inserted downstream of exon 1. (J:132905)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Socs1 Mutation: 29 strains or lines available

References

• Original: J:132905 Tanaka K, et al., Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads. J Immunol. 2008 Mar 15;180(6):3746-56
• All: 17 reference(s)