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Targeted Allele Detail
Symbol: Ern1tm1Dron
Name: endoplasmic reticulum (ER) to nucleus signalling 1; targeted mutation 1, David Ron
MGI ID: MGI:3778372
Synonyms: IRE1alpha-
Gene: Ern1  Location: Chr11:106397620-106487796 bp, - strand  Genetic Position: Chr11, 69.14 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:132966
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe exon encoding the transmembrane domain was deleted. The absence of protein was confirmed by western blot analysis. (J:132966)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ern1 Mutation:  8 strains or lines available
Original:  J:132966 Urano F, et al., Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 2000 Jan 28;287(5453):664-6
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory