Ern1^tm1Dron
Targeted Allele Detail

Summary

• Symbol: Ern1^tm1Dron
• Name: endoplasmic reticulum to nucleus signalling 1; targeted mutation 1, David Ron
• MGI ID: MGI:3778372
• Synonyms: IRE1alpha^-
• Gene: Ern1 Location: Chr11:106285476-106378678 bp, - strand Genetic Position: Chr11, 69.14 cM, cytoband E1
• Alliance: Ern1^tm1Dron page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132966
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The exon encoding the transmembrane domain was deleted. The absence of protein was confirmed by western blot analysis. (J:132966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ern1 Mutation: 57 strains or lines available

References

• Original: J:132966 Urano F, et al., Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science. 2000 Jan 28;287(5453):664-6
• All: 10 reference(s)