Ache^tm1Pata
Targeted Allele Detail

Summary

• Symbol: Ache^tm1Pata
• Name: acetylcholinesterase; targeted mutation 1, Palmer Taylor
• MGI ID: MGI:3778296
• Synonyms: achei1rr^FLOXED
• Gene: Ache Location: Chr5:137286516-137292728 bp, + strand Genetic Position: Chr5, 76.32 cM
• Alliance: Ache^tm1Pata page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of the intron regulatory region in intron 1 and an addtional loxP site was inserted upstream of the intron regulatory region in intron 1. Cre-mediated recombination in ES cells was used to remove the neo cassette and results in a floxed intron regulatory region in intron 1. (J:132775)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ache Mutation: 31 strains or lines available

References

• Original: J:132775 Camp S, et al., Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intron. J Neurosci. 2008 Mar 5;28(10):2459-70
• All: 1 reference(s)