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Transgene Detail
Symbol: Tg(Thy1-MAPT*P301S)2541Godt
Name: transgene insertion 2541, Michel Goedert
MGI ID: MGI:3778191
Synonyms: TauP301S, Tg2541
Transgene: Tg(Thy1-MAPT*P301S)2541Godt  Location: unknown  
Strain of Origin:  (C57BL/6J x CBA/Ca)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-MAPT*P301S)2541Godt expresses 1 gene
Mutation detailsThe neuron-specific promoter elements of the mouse Thy1 gene drive expression of the 383 amino acid isoform of human tau - the shortest of the isoforms having four microtubule binding repeats (0N4R) - in which proline is replaced by serine at amino acid position 301 of the protein (P301S). Immunoblot analysis demonstrates the presence of human tau at approximately twice the level of the combined endogenous mouse tau proteins in brains and spinal cords of 5-6 month old homozygous transgenic mice. (J:108870)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Homozygous transgenic lines were established from three founder mice. The data reported were obtained using mice of line 2541. (J:108870)
Original:  J:108870 Allen B, et al., Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002 Nov 1;22(21):9340-51
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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