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Tg(Thy1-MAPT*P301S)2541Godt
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-MAPT*P301S)2541Godt
Name: transgene insertion 2541, Michel Goedert
MGI ID: MGI:3778191
Synonyms: TauP301S
Transgene: Tg(Thy1-MAPT*P301S)2541Godt  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/Ca)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-MAPT*P301S)2541Godt expresses 1 gene
 
Mutation detailsThe neuron-specific promoter elements of the mouse Thy1 gene drive expression of the 383 amino acid isoform of human tau - the shortest of the isoforms having four microtubule binding repeats (0N4R) - in which proline is replaced by serine at amino acid position 301 of the protein (P301S). Immunoblot analysis demonstrates the presence of human tau at approximately twice the level of the combined endogenous mouse tau proteins in brains and spinal cords of 5-6 month old homozygous transgenic mice. (J:108870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Homozygous transgenic lines were established from three founder mice. The data reported were obtained using mice of line 2541. (J:108870)
References
Original:  J:108870 Allen B, et al., Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci. 2002 Nov 1;22(21):9340-51
All:  20 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory