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Transgene Detail
Symbol: Tg(TcraN15,TcrbN15)L2Elre
Name: transgene insertion L2, Ellis L Reinherz
MGI ID: MGI:3777745
Synonyms: N15tg
Transgene: Tg(TcraN15,TcrbN15)L2Elre  Location: unknown  
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(TcraN15,TcrbN15)L2Elre expresses 2 genes
Mutation detailsFertilized eggs homozygous for the null Rag2tm1Fwa allele were co-injected with transgenes encoding the rearranged Tcra and Tcrb genes isolated from the CD8 positive T cell clone N15. These transgenes encode a T cell receptor specific for the vesicular stomatitis virus nuclear octapeptide antigen (VSV8) presented by the MHC-I variant Kb. Expression of the transgenes by thymocytes was confirmed by flow cytometry analysis using an antibody specific for the transgenic TCR. (J:133112)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:133112 Ghendler Y, et al., Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol. 1997 Sep;27(9):2279-89
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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