About   Help   FAQ
Tg(TcraN15,TcrbN15)L2Elre
Transgene Detail
Nomenclature
Symbol: Tg(TcraN15,TcrbN15)L2Elre
Name: transgene insertion L2, Ellis L Reinherz
MGI ID: MGI:3777745
Synonyms: N15tg
Transgene: Tg(TcraN15,TcrbN15)L2Elre  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcraN15,TcrbN15)L2Elre expresses 2 genes
 
Mutation detailsFertilized eggs homozygous for the null Rag2tm1Fwa allele were co-injected with transgenes encoding the rearranged Tcra and Tcrb genes isolated from the CD8 positive T cell clone N15. These transgenes encode a T cell receptor specific for the vesicular stomatitis virus nuclear octapeptide antigen (VSV8) presented by the MHC-I variant Kb. Expression of the transgenes by thymocytes was confirmed by flow cytometry analysis using an antibody specific for the transgenic TCR. (J:133112)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:133112 Ghendler Y, et al., Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection. Eur J Immunol. 1997 Sep;27(9):2279-89
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory