Slc17a8^tm1Edw
Targeted Allele Detail

Summary

• Symbol: Slc17a8^tm1Edw
• Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; targeted mutation 1, Robert H Edwards
• MGI ID: MGI:3777601
• Synonyms: VGLUT3^-
• Gene: Slc17a8 Location: Chr10:89409882-89457111 bp, - strand Genetic Position: Chr10, 44.99 cM
• Alliance: Slc17a8^tm1Edw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132704
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 was replaced with an EGFP cassette, with a stop codon and poly-adenylation signal, and floxed neo cassette. Germ-line, cre-mediated recombination was used to remove the neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. However, no EGFP signal was detected. (J:132704)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc17a8 Mutation: 40 strains or lines available

References

• Original: J:132704 Seal RP, et al., Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24;57(2):263-75
• All: 15 reference(s)