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Targeted Allele Detail
Symbol: Slc17a8tm1Edw
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; targeted mutation 1, Robert H Edwards
MGI ID: MGI:3777601
Synonyms: VGLUT3-
Gene: Slc17a8  Location: Chr10:89409882-89457111 bp, - strand  Genetic Position: Chr10, 44.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:132704
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 2 was replaced with an EGFP cassette, with a stop codon and poly-adenylation signal, and floxed neo cassette. Germ-line, cre-mediated recombination was used to remove the neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. However, no EGFP signal was detected. (J:132704)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc17a8 Mutation:  31 strains or lines available
Original:  J:132704 Seal RP, et al., Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24;57(2):263-75
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory