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Sez6tm1.1Sest
Targeted Allele Detail
Summary
Symbol: Sez6tm1.1Sest
Name: seizure related gene 6; targeted mutation 1.1, Seong-Seng Tan
MGI ID: MGI:3777582
Gene: Sez6  Location: Chr11:77821626-77869874 bp, + strand  Genetic Position: Chr11, 46.74 cM
Alliance: Sez6tm1.1Sest page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132725
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. Transient cre expression in ES cells was used to remove exon 1. The absence of protein expression was confirmed by immunohistochemistry and western blot analysis on brain extracts. (J:132725)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sez6 Mutation:  71 strains or lines available
References
Original:  J:132725 Gunnersen JM, et al., Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Neuron. 2007 Nov 21;56(4):621-39
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory