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Cryaatm1.1Ady
Targeted Allele Detail
Nomenclature
Symbol: Cryaatm1.1Ady
Name: crystallin, alpha A; targeted mutation 1.1, Usha P Andley
MGI ID: MGI:3777403
Synonyms: alpha-R49C knock-in
Gene: Cryaa  Location: Chr17:31677945-31681724 bp, + strand  Genetic Position: Chr17, 17.09 cM, cytoband A3-B
Lens opacity in Cryaatm1.1Ady/Cryaa+, and Cryaatm1.1Ady/Cryaatm1.1Ady mice and microphthalmia in Cryaatm1.1Ady/Cryaatm1.1Ady mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132296
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation details
Generation of the Cryaatm1Ady anad Cryaatm1.1Ady alleles
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryaa Mutation:  4 strains or lines available
References
Original:  J:132296 Xi JH, et al., Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death. J Biol Chem. 2008 Feb 29;283(9):5801-14
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory