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Targeted Allele Detail
Symbol: Dab1tm1Bwh
Name: disabled 1; targeted mutation 1, Brian W Howell
MGI ID: MGI:3777252
Synonyms: Dab1cKIneo
Gene: Dab1  Location: Chr4:103619359-104744844 bp, + strand  Genetic Position: Chr4, 47.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:132599
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Conditional ready, Hypomorph, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon encoding amino acids 23 through 69 was replaced with a floxed cDNA of the open reading frame encoding amino acids 23 through 555 with a splice acceptor and a poly adenylation signal followed by a lacZ cassette with a splice acceptor and an frt-flanked neo cassette. This is also a reporter and hypomorphic allele. (J:132599)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dab1 Mutation:  42 strains or lines available
Original:  J:132599 Pramatarova A, et al., A genetic interaction between the APP and Dab1 genes influences brain development. Mol Cell Neurosci. 2008 Jan;37(1):178-86
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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