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Targeted Allele Detail
Symbol: Fkbp8tm1Kei
Name: FK506 binding protein 8; targeted mutation 1, Keiichi I Nakayama
MGI ID: MGI:3777160
Synonyms: Fkbp38-
Gene: Fkbp8  Location: Chr8:70527724-70535328 bp, + strand  Genetic Position: Chr8, 34.15 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:132541
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe 5.2-kb fragment extending from exon 3 through exon 7 was replaced with a PGK-neo selection cassette. The resulting allele lacks the first ATG codon as well as sequences encoding the FKBP domain and most of the three tetratricopeptide repeat domains. No translation products were detected by immunoblot analysis or by immunofluorescence anyalysis of mouse embryonic fibroblasts. (J:132961)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 21 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fkbp8 Mutation:  15 strains or lines available
Original:  J:132541 Nakagawa T, et al., Anchoring of the 26S proteasome to the organellar membrane by FKBP38. Genes Cells. 2007 Jun;12(6):709-19
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory