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CrygbS11R
Spontaneous Allele Detail
Nomenclature
Symbol: CrygbS11R
Name: crystallin, gamma B; S11R
MGI ID: MGI:3777015
Gene: Crygb  Location: Chr1:65119381-65121449 bp, - strand  Genetic Position: Chr1, 32.82 cM
Mutation
origin
Strain of Origin:  A/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsA T-to-G (A-to-C on negative gene strand) point mutation in codon 11 results in the substitution of serine with arginine at position 11 (p.S11R). (J:132502)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crygb Mutation:  12 strains or lines available
References
Original:  J:132502 Li L, et al., Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):304-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory