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Tjp2tm1Whun
Targeted Allele Detail
Nomenclature
Symbol: Tjp2tm1Whun
Name: tight junction protein 2; targeted mutation 1, Walter Hunziker
MGI ID: MGI:3776874
Synonyms: ZO-2-
Gene: Tjp2  Location: Chr19:24094505-24225030 bp, - strand  Genetic Position: Chr19, 19.17 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132649
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ cassette and floxed neo cassette were inserted into exon 2 following the translation initiation site. The absence of protein product was confirmed by western blot analysis and immunofluorescence. (J:132649)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tjp2 Mutation:  76 strains or lines available
References
Original:  J:132649 Xu J, et al., Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol Cell Biol. 2008 Mar;28(5):1669-78
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory