Apln^tm1Tq
Targeted Allele Detail

Summary

• Symbol: Apln^tm1Tq
• Name: apelin; targeted mutation 1, Thomas Quertermous
• MGI ID: MGI:3776530
• Synonyms: apelin^LacZ
• Gene: Apln Location: ChrX:47114023-47123730 bp, - strand Genetic Position: ChrX, 25.48 cM, cytoband A3.2
• Alliance: Apln^tm1Tq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132420
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene with a nuclear localization signal was placed immediately upsteam of the translation initiation site in exon 1 (unpublished). (J:132420)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apln Mutation: 13 strains or lines available

References

• Original: J:132420 Sheikh AY, et al., In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H88-98
• All: 22 reference(s)