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Gt(ROSA)26Sortm1(ptxA)Cgh
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(ptxA)Cgh
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Shaun R Coughlin
MGI ID: MGI:3776029
Synonyms: ROSA26PTX
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130781
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsA splice acceptor, floxed neo cassette and ptxA (pertussis toxin subunit 1) were knocked into intron 1. Removal of the neo cassette by cre-mediated recombination will result in the expresson of ptxA. (J:130781)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  288 strains or lines available
References
Original:  J:130781 Regard JB, et al., Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest. 2007 Dec;117(12):4034-43
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory