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Mfsd7btm1Jlab
Targeted Allele Detail
Nomenclature
Symbol: Mfsd7btm1Jlab
Name: major facilitator superfamily domain containing 7B; targeted mutation 1, Janis L Abkowitz
MGI ID: MGI:3776021
Synonyms: Flvcrflox
Gene: Mfsd7b  Location: Chr1:191005847-191026158 bp, - strand  Genetic Position: Chr1, 96.28 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132057
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 3. The neo cassette was removed by transient cre-mediated recombination to leave a floxed exon 3. (J:132057)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mfsd7b Mutation:  4 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Diamond-Blackfan Anemia in homozygous mice carrying Tg(Mx1-cre)1Cgn (J:132057)

References
Original:  J:132057 Keel SB, et al., A heme export protein is required for red blood cell differentiation and iron homeostasis. Science. 2008 Feb 8;319(5864):825-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory