Ip6k1^tm1.1Snyd
Targeted Allele Detail

Summary

• Symbol: Ip6k1^tm1.1Snyd
• Name: inositol hexaphosphate kinase 1; targeted mutation 1.1, Solomon Snyder
• MGI ID: MGI:3775918
• Synonyms: IP6K1^-
• Gene: Ip6k1 Location: Chr9:107879847-107925981 bp, + strand Genetic Position: Chr9, 59.07 cM, cytoband F2
• Alliance: Ip6k1^tm1.1Snyd page

Impaired spermiogenesis in Ip6k1^tm1.1Snyd/Ip6k1^tm1.1Snyd mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132167
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The first part of exon 6 that contains the C-terminal coding region was removed by germ-line, cre-mediated recombination. The absence of transcript was confirmed by RT-PCR analysis on brain and liver extracts. (J:132167)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ip6k1 Mutation: 70 strains or lines available

References

• Original: J:132167 Bhandari R, et al., Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2349-53
• All: 16 reference(s)