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Targeted Allele Detail
Symbol: Nrastm1Tyj
Name: neuroblastoma ras oncogene; targeted mutation 1, Tyler Jacks
MGI ID: MGI:3775824
Synonyms: NrasG12D, NrasLSL-G12D
Gene: Nras  Location: Chr3:102965601-102975230 bp, + strand  Genetic Position: Chr3, 45.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:132357
Parent Cell Line:  V26.2 (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to include a lox-stop-lox element in intron 1 (to suppress expression in the absence of Cre recombinase) and a G12D activating mutation in exon 2. (J:132357)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nras Mutation:  42 strains or lines available
Phenotypic Similarity to Human Syndrome: Primary Melanoma of the CNS (J:198244) in mice homozygous for Nrastm1Tyj and hemizygous for Tg(Tyr-cre)1Lru.
Original:  J:132357 Haigis KM, et al., Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008 Mar 30;40(5):600-8
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory