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Targeted Allele Detail
Symbol: Itih4tm1Mish
Name: inter alpha-trypsin inhibitor, heavy chain 4; targeted mutation 1, Lopa Mishra
MGI ID: MGI:3775819
Gene: Itih4  Location: Chr14:30886476-30901981 bp, + strand  Genetic Position: Chr14, 19.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:132133
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on liver tissue extracts. (J:132133)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itih4 Mutation:  38 strains or lines available
Original:  J:132133 Tang Y, et al., Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2445-50
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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