Itih4^tm1Mish
Targeted Allele Detail

Summary

• Symbol: Itih4^tm1Mish
• Name: inter alpha-trypsin inhibitor, heavy chain 4; targeted mutation 1, Lopa Mishra
• MGI ID: MGI:3775819
• Gene: Itih4 Location: Chr14:30608433-30623943 bp, + strand Genetic Position: Chr14, 19.09 cM
• Alliance: Itih4^tm1Mish page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132133
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on liver tissue extracts. (J:132133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itih4 Mutation: 60 strains or lines available

References

• Original: J:132133 Tang Y, et al., Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2445-50
• All: 2 reference(s)