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Del(5Cyp3a57-Cyp3a59)2Nki
Targeted Allele Detail
Nomenclature
Symbol: Del(5Cyp3a57-Cyp3a59)2Nki
Name: deletion, Chr 5, The Netherlands Cancer Institute 2
MGI ID: MGI:3775604
Synonyms: Cyp3atm1.1Ahs, Del1Ahs, Del2Nki, Del(5Cyp3a57-Cyp3a59)1Ahs
Gene: Del(5Cyp3a57-Cyp3a59)2Nki  Location: Chr5:145282089-146050097 bp  Genetic Position: Chr5, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:127366
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Intergenic deletion, Intragenic deletion
  Del(5Cyp3a57-Cyp3a59)2Nki involves 17 genes/genome features (Cyp3a57, Gm2314, Cyp3a16 ...) View all
 
Mutation detailsThe intronic sequence between exon 2 and 3 of Cyp3a57 was replaced with a floxed neo cassette and 2.2 kb downstream of exon 13 a thymidine kinase and a floxed hygromycin cassette were inserted into the genomic sequence of Cyp3a59. Transfection of ES cells with a cre recombinase resulted in the deletion of Cyp3a57, Cyp3a16, Cyp3a41, Cyp3a44, Cyp3a11, Cyp3a25 and Cyp3a59. (J:127366)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(5Cyp3a57-Cyp3a59)2Nki Mutation:  0 strains or lines available
References
Original:  J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory