About   Help   FAQ
Ptrh2tm1.1Eruo
Targeted Allele Detail
Summary
Symbol: Ptrh2tm1.1Eruo
Name: peptidyl-tRNA hydrolase 2; targeted mutation 1.1, Erkki Ruoslahti
MGI ID: MGI:3775076
Synonyms: Bit1-
Gene: Ptrh2  Location: Chr11:86574900-86583283 bp, + strand  Genetic Position: Chr11, 51.82 cM
Alliance: Ptrh2tm1.1Eruo page
Ptrh2tm1.1Eruo/Ptrh2tm1.1Eruo mice exhibit stunted growth after birth

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131853
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsGerm-line cre-mediated recombination was used to remove the open reading frame. The absence of protein product was confirmed by western blot analysis on E14.5 embryo extracts. (J:131853)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptrh2 Mutation:  35 strains or lines available
References
Original:  J:131853 Kairouz-Wahbe R, et al., Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1528-32
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory