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Ptrh2tm1.1Eruo
Targeted Allele Detail
Nomenclature
Symbol: Ptrh2tm1.1Eruo
Name: peptidyl-tRNA hydrolase 2; targeted mutation 1.1, Erkki Ruoslahti
MGI ID: MGI:3775076
Synonyms: Bit1-
Gene: Ptrh2  Location: Chr11:86574900-86583283 bp, + strand  Genetic Position: Chr11, 51.82 cM
Ptrh2tm1.1Eruo/Ptrh2tm1.1Eruo mice exhibit stunted growth after birth

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131853
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsGerm-line cre-mediated recombination was used to remove the open reading frame. The absence of protein product was confirmed by western blot analysis on E14.5 embryo extracts. (J:131853)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptrh2 Mutation:  35 strains or lines available
References
Original:  J:131853 Kairouz-Wahbe R, et al., Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1528-32
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory