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Mapk8tm1Rjd
Targeted Allele Detail
Nomenclature
Symbol: Mapk8tm1Rjd
Name: mitogen-activated protein kinase 8; targeted mutation 1, Roger J Davis
MGI ID: MGI:3775057
Synonyms: Jnk1LoxP, Mapk8tm2Flv
Gene: Mapk8  Location: Chr14:33377898-33447158 bp, - strand  Genetic Position: Chr14, 20.22 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131766
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of the exon containing the TPY activation loop and an aditional loxP site was inserted downstream of that exon. The neo cassette was removed by cre-mediated recombination (no details given). (J:131766)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapk8 Mutation:  40 strains or lines available
References
Original:  J:131766 Das M, et al., Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15759-64
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory