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Tg(ACTA1-SMN)69Ahmb
Transgene Detail
Nomenclature
Symbol: Tg(ACTA1-SMN)69Ahmb
Name: transgene insertion 69, Arthur H M Burghes
MGI ID: MGI:3774944
Synonyms: HSA69-SMN
Transgene: Tg(ACTA1-SMN)69Ahmb  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ACTA1-SMN)69Ahmb expresses 1 gene
 
Mutation detailsThe HSA-SMN transgene was designed with the human alpha-skeletal actin (HSA or ACTA1) promoter region, splice acceptor site from the SV40 VP1 intron, full-length humsn SMN cDNA (containing exons 1-8), and two SV40 polyA signals. Mice from founder line 69 (HSA69-SMN) were found to have 11 copies of the transgene. (J:97103, J:131663)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:131663 Gavrilina TO, et al., Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle specific SMN expression has no phenotypic effect. Hum Mol Genet. 2008 Jan 4;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory