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Tfv1C57BL/6J
QTL Variant Detail
Nomenclature
QTL variant: Tfv1C57BL/6J
Name: total food volume 1; C57BL/6J
MGI ID: MGI:3774624
QTL: Tfv1  Location: Chr17:4804477-65330362 bp  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:131443

A QTL for total food volume intake mapped to 14 cM on mouse Chromosome 17 near D17Mit198 (LOD=7.6). This locus was mapped in an existing cross of 502 (C57BL/6J x CAST/EiJ)F2 animals and is designated Tfv1 (total food volume 1). The Tfv1 interval spans 10cM - 26 cM. F2 animals were assessed at 7-10 weeks of age for food intake. Genome scan was performed using 98 polymorphic markers at a 20 cM resolution. Parental strain CAST/EiJ consumes more food compared to parental strain C57BL/6J over the same period of time.

Tfv1 was confirmed using a congenic line carrying CAST/EiJ-derived DNA on chromosome 17 from 3 cM (D17Mit19) to 37.8 cM (D17Mit91) on a C57BL/6J genetic background. Congenic animals displayed higher consumed food volume over a 10-day period compared to C57BL/6J control animals. Congenic animals also displayed a higher rate of gastric emptying compared to C57BL/6J controls.

The Tfv1 interval coincides with previously identified QTLs Mnic1 (20 cM) and Kcal2 (20 cM). Potential candidate gene Glp1r (18 cM) maps to this interval and displays decreased gene expression in congenic animals compared to C57BL/6J controls.

References
Original:  J:131443 Kumar KG, et al., Genetic variation in Glp1r expression influences the rate of gastric emptying in mice. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R362-71
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory