Notch1^tm2.1Pst
Targeted Allele Detail

Summary

• Symbol: Notch1^tm2.1Pst
• Name: notch 1; targeted mutation 2.1, Pamela Stanley
• MGI ID: MGI:3774554
• Synonyms: Notch1^lbd
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm2.1Pst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131563
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 6 through 8 were deleted by germ-line cre-meditated recombination. (J:131563)

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 115 strains or lines available

References

• Original: J:131563 Ge C, et al., The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1539-44
• All: 5 reference(s)