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Notch1tm2.1Pst
Targeted Allele Detail
Nomenclature
Symbol: Notch1tm2.1Pst
Name: notch 1; targeted mutation 2.1, Pamela Stanley
MGI ID: MGI:3774554
Synonyms: Notch1lbd
Gene: Notch1  Location: Chr2:26457903-26516663 bp, - strand  Genetic Position: Chr2, 18.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131563
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
    Exons 6 through 8 were deleted by germ-line cre-meditated recombination. (J:131563)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  32 strains or lines available
References
Original:  J:131563 Ge C, et al., The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1539-44
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory