Tg(Nes-cre/ERT2)1Fsh
Transgene Detail

Summary

• Symbol: Tg(Nes-cre/ERT2)1Fsh
• Name: transgene insertion 1, Gordon Fishell
• MGI ID: MGI:3774417
• Synonyms: Nestin^CreERT2, Tg(Nes-cre/ESR1)1Fsh
• Transgene: Tg(Nes-cre/ERT2)1Fsh Location: unknown
• Alliance: Tg(Nes-cre/ERT2)1Fsh page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nes-cre/ERT2)1Fsh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Nes

• Mutation details: The intron 2 neural-specific enhancer from intron 2 was used to drive expression of an inducible cre/ESR1 (ET2) fusion in neural tissues. (J:130973)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (species not specified) Summary of all recombinase alleles driven by Nes. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four lines were created and the one utilized exhibited an intermediate level of expression

References

• Original: J:130973 Balordi F, et al., Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. J Neurosci. 2007 Dec 26;27(52):14248-59
• All: 26 reference(s)