Tnfrsf10b^tm1.1Cjk
Targeted Allele Detail

Summary

• Symbol: Tnfrsf10b^tm1.1Cjk
• Name: tumor necrosis factor receptor superfamily, member 10b; targeted mutation 1.1, Christopher J Kemp
• MGI ID: MGI:3774334
• Synonyms: Trail-r^-
• Gene: Tnfrsf10b Location: Chr14:70004921-70021860 bp, + strand Genetic Position: Chr14, 36.1 cM
• Alliance: Tnfrsf10b^tm1.1Cjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130806
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 was deleted by germ-line, cre-mediated recombination. The absence of protein product was confirmed by immunohistochemistry. (J:130806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf10b Mutation: 28 strains or lines available

References

• Original: J:130806 Grosse-Wilde A, et al., TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest. 2008 Jan;118(1):100-10
• All: 3 reference(s)