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Gfra1tm3Jmi
Targeted Allele Detail
Nomenclature
Symbol: Gfra1tm3Jmi
Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 3, Jeffrey Milbrandt
MGI ID: MGI:3774317
Synonyms: Gfra1TLZ, GFRalpha1TLZ
Gene: Gfra1  Location: Chr19:58235604-58455909 bp, - strand  Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130616
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA tau-lacZ and neo cassette was inserted into the second exon deleting 95 bp of the 5' untranslated region including the start codon. The neo cassette was removed by germ-line, cre-mediated recombination. LacZ expression recapitulated endogenous promoter expression. Absence of target expression was confirmed by in situ hybridization. This is a null allele. (J:130616)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gfra1 Mutation:  5 strains or lines available
References
Original:  J:130616 Enomoto H, et al., GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron. 2004 Nov 18;44(4):623-36
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory