Gfra1^tm3Jmi
Targeted Allele Detail

Summary

• Symbol: Gfra1^tm3Jmi
• Name: glial cell line derived neurotrophic factor family receptor alpha 1; targeted mutation 3, Jeffrey Milbrandt
• MGI ID: MGI:3774317
• Synonyms: Gfra1^TLZ, GFRalpha1^TLZ
• Gene: Gfra1 Location: Chr19:58224036-58444341 bp, - strand Genetic Position: Chr19, 54.18 cM, cytoband D2-D3
• Alliance: Gfra1^tm3Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130616
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A tau-lacZ and neo cassette was inserted into the second exon deleting 95 bp of the 5' untranslated region including the start codon. The neo cassette was removed by germ-line, cre-mediated recombination. LacZ expression recapitulated endogenous promoter expression. Absence of target expression was confirmed by in situ hybridization. This is a null allele. (J:130616)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra1 Mutation: 31 strains or lines available

References

• Original: J:130616 Enomoto H, et al., GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron. 2004 Nov 18;44(4):623-36
• All: 6 reference(s)