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Kcnb1tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Kcnb1tm1Dgen
Name: potassium voltage gated channel, Shab-related subfamily, member 1; targeted mutation 1, Deltagen
MGI ID: MGI:3774269
Synonyms: Kv2.1-
Gene: Kcnb1  Location: Chr2:167095969-167190072 bp, - strand  Genetic Position: Chr2, 87.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:129963
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe genomic sequence for codon 346 through 380 was replaced with an IRES-lacZ-neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. This is a null allele. (J:129963)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnb1 Mutation:  22 strains or lines available
References
Original:  J:129963 Jacobson DA, et al., Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell Metab. 2007 Sep;6(3):229-35
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory