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Ubbtm1Rrk
Targeted Allele Detail
Summary
Symbol: Ubbtm1Rrk
Name: ubiquitin B; targeted mutation 1, Ron R Kopito
MGI ID: MGI:3774112
Gene: Ubb  Location: Chr11:62442329-62444037 bp, + strand  Genetic Position: Chr11, 38.46 cM
Alliance: Ubbtm1Rrk page
Adult-onset obesity in Ubbtm1Rrk/Ubbtm1Rrk mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130361
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding exon was replaced with a promoterless GFP-puro fusion cassette. Expression of the GFP was confirmed by qRT-PCR. The authors state that this is a null allele. (J:130361)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ubb Mutation:  18 strains or lines available
References
Original:  J:130361 Ryu KY, et al., The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol. 2008 Feb;28(3):1136-46
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory