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Targeted Allele Detail
Symbol: Map1lc3btm1Mrab
Name: microtubule-associated protein 1 light chain 3 beta; targeted mutation 1, Marlene Rabinovtich
MGI ID: MGI:3774111
Synonyms: LC3B-
Gene: Map1lc3b  Location: Chr8:121590361-121598760 bp, + strand  Genetic Position: Chr8, 70.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:130322
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe second amino acid encoded by exon 3 was replaced with a stop translation codon and the remainder of exon 3 and exon 4 were replaced with an IRES Tau-LacZ and neo cassette. The absence of endogenous protein product was confirmed on E14.5 head and trunk extracts and E18.5 head extracts. Beta-galactosidase is not expressed from this allele. (J:130322)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 9 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map1lc3b Mutation:  20 strains or lines available
ES cell line = CGR8.8 (subline of CGR8)
Original:  J:130322 Cann GM, et al., Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice. Dev Dyn. 2008 Jan;237(1):187-95
All:  8 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
The Jackson Laboratory