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Ednratm1Hku
Targeted Allele Detail
Nomenclature
Symbol: Ednratm1Hku
Name: endothelin receptor type A; targeted mutation 1, Hiroki Kurihara
MGI ID: MGI:3773699
Synonyms: Ednraneo
Gene: Ednra  Location: Chr8:77663029-77724452 bp, - strand  Genetic Position: Chr8, 36.63 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131382
Parent Cell Line:  ATOM1 (ES Cell)
Strain of Origin:  (C57BL/6 x 129)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette with a poly adenylation signal was inserted and replaces part of exon 2. Authors state that this is a null allele. (J:131382)
Recombinase-mediated cassette exchange to generate the first-step targeted (Ednratm1Hku), lacZ-knocked-in (Ednratm2.1Hku), Edn1-knocked-in (Ednratm6(Edn1)Hku), and Hand2-knocked-in (Ednratm7(Hand2)Hku) alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ednra Mutation:  7 strains or lines available
References
Original:  J:131382 Sato T, et al., Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development. Development. 2008 Feb;135(4):755-65
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory