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Phox2btm2Jbr
Targeted Allele Detail
Nomenclature
Symbol: Phox2btm2Jbr
Name: paired-like homeobox 2b; targeted mutation 2, Jean-Francois Brunet
MGI ID: MGI:3773691
Synonyms: Phox2b27Ala
Gene: Phox2b  Location: Chr5:67094405-67099301 bp, - strand  Genetic Position: Chr5, 35.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131365
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phox2b Mutation:  7 strains or lines available
References
Original:  J:131365 Dubreuil V, et al., A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons. Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):1067-72
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory