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Ier3tm1Raku
Targeted Allele Detail
Summary
Symbol: Ier3tm1Raku
Name: immediate early response 3; targeted mutation 1, Rajiv Kumar
MGI ID: MGI:3773690
Synonyms: gly96/IEX-1-, IEX-1 KO
Gene: Ier3  Location: Chr17:36132605-36133803 bp, + strand  Genetic Position: Chr17, 18.7 cM
Alliance: Ier3tm1Raku page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131099
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a targeting vector replaced both exons and intron 1 with a neo resistance cassette. RT-PCR did not detect transcript in eight tissues tested. (J:131099)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ier3 Mutation:  11 strains or lines available
References
Original:  J:131099 Sommer SL, et al., Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J Appl Physiol. 2006 Feb;100(2):707-16
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory