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Ier3tm1Raku
Targeted Allele Detail
Nomenclature
Symbol: Ier3tm1Raku
Name: immediate early response 3; targeted mutation 1, Rajiv Kumar
MGI ID: MGI:3773690
Synonyms: gly96/IEX-1-, IEX-1 KO
Gene: Ier3  Location: Chr17:35821684-35822923 bp, + strand  Genetic Position: Chr17, 18.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131099
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a targeting vector replaced both exons and intron 1 with a neo resistance cassette. RT-PCR did not detect transcript in eight tissues tested. (J:131099)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ier3 Mutation:  7 strains or lines available
References
Original:  J:131099 Sommer SL, et al., Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J Appl Physiol. 2006 Feb;100(2):707-16
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory