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Tead2tm1Hssk
Targeted Allele Detail
Nomenclature
Symbol: Tead2tm1Hssk
Name: TEA domain family member 2; targeted mutation 1, Hiroshi Sasaki
MGI ID: MGI:3773644
Gene: Tead2  Location: Chr7:45215753-45233636 bp, + strand  Genetic Position: Chr7, 29.19 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131426
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA DNA fragment encompassing the second and third exons and small segments of the first and third introns has been replaced by a cassette comprising an engrailed 2 splice acceptor (SA) followed by an internal ribosome entry site (IRES), the beta-galactosidase/neomycin fusion gene Betageo, and a polyadenylation signal. Although in homozygous mutant mice, no transcripts containing the deleted exons or exons 10-11 are detected by reverse transcription- (RT-) PCR, transcripts including exons 4-6 and 6-8 are detected; any translation products would be non-functional, lacking portions of the DNA binding and/or coactivator interaction domains. (J:131426)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tead2 Mutation:  20 strains or lines available
References
Original:  J:131426 Sawada A, et al., Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008 May;28(10):3177-89
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory