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Tead1tm1Hssk
Targeted Allele Detail
Nomenclature
Symbol: Tead1tm1Hssk
Name: TEA domain family member 1; targeted mutation 1, Hiroshi Sasaki
MGI ID: MGI:3773642
Gene: Tead1  Location: Chr7:112679318-112906807 bp, + strand  Genetic Position: Chr7, 58.8 cM, cytoband F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131426
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA DNA fragment containing exon 2 and small segments of the flanking introns has been replaced by a loxP-flanked Pgk-neo-poly(A) cassette and a second cassette comprising an engrailed 2 splice acceptor (SA) followed by an internal ribosome entry site (IRES), the beta-galactosidase/neomycin fusion gene Betageo, and a polyadenylation signal. Reverse transcription- (RT-) PCR with primers for two downstream segments (exons 7-9 and 10-11) detects no transcripts in homozygous mutant embryos. (J:131426)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tead1 Mutation:  259 strains or lines available
References
Original:  J:131426 Sawada A, et al., Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008 May;28(10):3177-89
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory